INS and type 2 diabetes mellitus: It is of note that among the microRNA up-regulated by HG, we also got miR-125a and miR-320, which were previously found to be overexpressed in type 2 diabetes Goto Kakizaki rats, where they were induced in insulin-targeted tissues (liver and adipose tissue) and in microvascular endothelial cells (MMVEC) respectively [18, 19].