These phosphatases also play crucial role in conferring resistance to radiation and chemo therapies; Eke et al. (2010) recently demonstrated that an adapter protein, downstream of focal adhesion, PINCH1 [5 Lin-1, Isl-1, Mec-3 (LIM) domain – containing particularly interesting new cysteine-histidine-rich 1], inhibits protein phosphatase 1α and confers resistance to cancer cells against ionizing radiation and chemo therapies by increasing the Akt phosphorylation. This evidence concerns the gene AKT1 and cancer.