Indeed, we have found that mice receiving subcutaneous injections of CXCL10 (100 ng) at days 1, 3, and 7 of infection with L. amazonensis have attenuated cutaneous lesions, as well as a 7- and 3.5-fold increase in IFN-γ and IL-12 production in re-stimulated lymph node cells (Vasquez and Soong, 2006). This evidence concerns the gene IFNG and infection.