IFNG and cutaneous leishmaniasis: It has been reported that the crude antigen extracts of L. braziliensis (LbAg) are more potent than antigens of L. amazonensis (LaAg) in stimulating IFN-γ-producing cells and multi-functional CD4+ T cells of American cutaneous leishmaniasis patients (Macedo et al., 2012), and that LbAg also stimulate CXCL10 production in human PMBC, in a manner that correlates to the IFN-γ-positivity but not DTH-positivity (Schnorr et al., 2012).