IL2 and Autoimmunity: In addition, polymorphisms in IL-2, CD25, or downstream adaptors genes are associated with impaired Treg numbers or function and higher susceptibility to autoimmunity (Bottini et al., 2004; Vella et al., 2005; Todd et al., 2007; Yamanouchi et al., 2007; Liston et al., 2008; Sgouroudis et al., 2008, 2011).