FOXP3 and colitis: Examples where chronic inflammation may support iTreg development include mouse models of asthma (Curotto de Lafaille et al., 2008; Weiss et al., 2012), colitis that occurs during T cell expansion in a lymphopenic environment (Haribhai et al., 2009), adoptive transfer immunotherapy for the treatment of Foxp3-deficiency (Haribhai et al., 2011), and infection with intestinal parasites (Grainger et al., 2010).