In agreement with that notion, perivascular nerve deficits and/or degeneration were detected in different cardiovascular diseases with exaggerated angiotensin II generation such as hypertension, diabetes, and atherosclerosis (Webster et al., 1991; Scott et al., 1992; Verbeuren et al., 1994; Hobara et al., 2005). This evidence concerns the gene AGT and cardiovascular disorder.