Concomitantly, inhibition of angiotensin II generation or angiotensin II AT1 receptor antagonism/deficiency retarded the development of atherosclerosis in animal models of atherosclerosis and patients with cardiovascular disease (Hayek et al., 1998; Yusuf et al., 2000; Abd Alla et al., 2004; Wassmann et al., 2004). The gene discussed is AGT; the disease is cardiovascular disorder.