EGFR and Erythema: Some patients receiving EGFR-targeted agents have been reported to show widespread erythema, infiltration and pustules in sun-exposed areas.19,53,54 One randomized study, N05C4, conducted in the US by NCCTG, has investigated the prophylactic use of SPF60 sunscreen in cancer patients receiving an EGFR-targeted agent as part of their therapy.39