Moreover, patients with high sCD163/sTWEAK ratio had lower risk of DU (Table 2): 5 out of 29 (17%) of the SSc patients with high sCD183/sTWEAK ratio had DU at the time of the study compared with 33 out of 60 (55%) of those with normal sCD183/sTWEAK ratio (OR 0.17, 95% CI 0.06, 0.51; P <0.05). The gene discussed is CD163; the disease is systemic sclerosis.