CD5 and peeling skin syndrome: In our study we found higher proportions of CD19+/CD24hi/CD38hi/CD5+ IL-10-secreting B cells in pSS patients with clinically inactive disease compared to those with clinically active disease, the whole pSS group, and healthy controls, suggesting that CD5+ IL-10-producing B cells are able to downregulate autoimmune inflammation to induce homeostasis [5-8].