In the FTD series the association was observed to be stronger in the clinical series (OR = 5.46; p-value=0.0009) compared to the pathologic-confirmed cases with frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP, OR = 3.56, p=0.14); however this could be, at least in part, related to the smaller autopsy series (n=132). Here, TARDBP is linked to frontotemporal dementia.