GJA1 and hepatocellular carcinoma: Ogawa et al. established six rat HCC cell lines that exhibited different metastatic potentials after inoculation into the tail veins of nude mice and transfection of an siRNA targeting Cx43 (as shown by cDNA array analysis), indicating that suppression of Cx43 expression in tumor cells reduced in vitro migration and invasion capacity and in vivo metastatic ability [24].