(a) The vasculature delivers oxygen, cytokine, and glucose to the tumor microenvironment in the tissue level; (b) The melanoma cells uptake the glucose for metabolism as well as switch the phenotype under the stimulation of specific cytokine in the intercellular scale; (c) In turn, the inadequate glucose and oxygen will stimulate the tumor cell to secrete the VEGF in the intercellular level to induce angiogenesis. Here, VEGFA is linked to melanoma.