Also suggesting an anti-inflammatory polarity in CFS, Skowera et al. (2004) [13] reported relatively high levels of intracellular IL-4 and IL-10 following in vitro polyclonal stimulation of whole blood from a mixed population of males and females (n = 13 males and 22 females; age 39 ± 2.1 years [19–62 years]). Here, IL4 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.