STAT3 and colorectal carcinoma: Data from Figure 5 indicated that the percentage of pSTAT3-positive cells in control or EESP-treated mice was 41.71 ± 6.59% and 18.24 ± 3.63%, respectively (P < 0.01), suggesting that EESP treatment significantly suppresses the activation of STAT3 pathway in CRC mice.