PCR data showed that EESP treatment significantly reduced the mRNA expression of pro-proliferative Cyclin D1 and CDK4, anti-apoptotic Bcl-2, pro-angiogenic VEGF-A and VEGFR-2 in CRC mice, whereas that of pro-apoptotic Bax was significantly increased after EESP treatment (Figure 6A). Here, CCND1 is linked to colorectal carcinoma.