Consistent with the role of HTATIP2/TIP30 in the suppression of tumor growth and metastasis via transcription mechanisms, studies have revealed that the ectopic expression of HTATIP2/TIP30 in tumor cell lines upregulates the expression of pro-apoptotic factors [12] and angiogenic inhibitors, and downregulates the expression of angiogenic stimulators [14]. Here, HTATIP2 is linked to neoplasm.