In nude mice esophageal carcinoma cell xenografts model, expression of CXCR4 mRNA in CXCR4 siRNA1 and CXCR4 siRNA2 group were lower significantly than in negative control and blank control group (Figure 6), The results showed that CXCR4 siRNA inhibited xenografts tumor tissue CXCR4 mRNA expression effectively in vivo. Here, CXCR4 is linked to neoplasm.