LEP and androgen insensitivity syndrome: Grivas et al. suggest here that the phenotypic sexual dimorphism of normal TAs is related to the onset and timing of puberty including the combination of three components, namely: 1) secondary sexual development affecting body composition, with girls depositing more white adipose tissue than boys, affecting circulating leptin levels; 2) adolescent skeletal growth velocity and 3) a putative asymmetry process as suggested recently for AIS girls[11,12].