Because in recent studies a new population of FoxP3+ regulatory T-cells has been described that shares features with TFH cells by expressing the transcription factor BCL-6, we also evaluated whether the increase in BCL-6+ T-cells in GPA patients was a result of an increase in FoxP3+BCL-6+ T-cells [36,37]. The gene discussed is BCL6; the disease is granulomatosis with polyangiitis.