FOXO1 and neoplasm: Because high levels of PAX3-FKHR transcript and protein are detected in all t(2;13)-positive ARMS tumors and tumor-derived cell lines, and continuous expression of PAX3-FKHR is critical for maintaining ARMS phenotypes and cell survival [13], research efforts have focused exclusively on characterizing PAX3-FKHR gene products and their contribution to rhabdomyosarcomagenesis.