CCL2 and asthma: For example, in studies of respiratory secretions, Gern et al reported that experimental infection of allergic individuals with HRV 16 resulted in increased levels of IL-8 and granulocyte colony stimulating factor (GCSF) [27], Miller et al found an association between increased levels of Type III IFN-λ and wheezing with HRV infection in patients with asthma [28] and Garcia et al noted lower levels of MCP-1 and IL-1Ra associated with increased severity of HRV infection [29].