Increased RBBP6 expression was significantly associated with depth of tumor invasion (pT stage, P = 0.005), LNM (pN stage, P = 0.002), distant metastasis (M stage, P<0.001), advanced AJCC (P<0.001) and differentiation (P = 0.007) (Table 2). Here, RBBP6 is linked to neoplasm.