Several components of the thioredoxin system are closely linked to LRRK2, including PRDX3, TXNIP, and TXNRD1, which have been identified in recent years as risk factors for obesity and diabetes in human subjects, and as nutrient sensing mechanisms and controlling factors of adipogenesis in mice [29]–[31]. Here, TXNIP is linked to obesity due to melanocortin 4 receptor deficiency.