TXNRD1 and obesity due to melanocortin 4 receptor deficiency: Molecular pathway analysis of LRRK2 reveals direct links between LRRK2 and the thioredoxin system (Figure 5), which interacts with PRDX3, TXNIP and TXNRD1, proteins that are associated with nutrient sensing, adiposity and human obesity [29], [37], [38].