Molecular pathway analysis of LRRK2 reveals direct links between LRRK2 and the thioredoxin system (Figure 5), which interacts with PRDX3, TXNIP and TXNRD1, proteins that are associated with nutrient sensing, adiposity and human obesity [29], [37], [38]. Here, TXN is linked to obesity due to melanocortin 4 receptor deficiency.