Of the significantly targeted pathways the most relevant to cardiac physiology and pathophysiology were the Ubiquitin-mediated Proteolysis pathway (Benjamini corrected P = 7.12×10−7; 46 targets), Mitogen-Activated Protein Kinase pathway (MAPKinase; P = 1.86×10−6; 75 targets; Fig. 11), Regulation of Actin Cytoskeleton (P = 2.29×10−4; 56 targets), Wnt pathways (P = 3.45×10−4; 42 targets), Calcium Signaling (P = 5.01×10−4; 49 targets), Gap junctions (P = 6.43×10−4; 27 targets) and Arrhythmogenic Right Ventricular Cardiomyopathy pathway (ARVC; P = 0.047; 20 targets). Here, WNK2 is linked to Right ventricular cardiomyopathy.