RAF1 and cardiac hypertrophy: Interestingly the Ras gene family within this pathway was predicted to be targeted by 14 of the top 16 highest detected miRNAs; this family of genes as a part of the Ras/Raf-1/MEK/ERK cascade is generally regarded as playing a highly significant role in cardiac hypertrophy, myocardial cell death and myocardial remodelling [151].