In Lewis lung carcinoma, neither rh-endostatin (3394.7±668.4 vs 3866.5±490.62, p = 0.176) nor CIK cells therapy (3429.6±579.12 vs 3866.5±490.62, p = 0.208) alone exhibited obvious inhibition on tumor growth compared with the NS control. Here, COL18A1 is linked to neoplasm.