TGFB1 and neoplasm: The possible mechanism is that angiogenesis in the tumor may be driven by additional factors, such as fibroblast growth factor 1 (FGF-1), FGF-2, transforming growth factor-β (TGF-β), platelet-derived endothelial cell growth factor (PD-ECGF), and placental growth factor (PIGF) [35].