In SPC-A1 lung cancer model, compared with NS control, rh-endostatin (1152.8±181.4 vs 1284.7±229.2, p = 0.527) and CIK (1204.1±536.2 vs 1284.7±229.2, p = 0.698) monotherapy did not show any significant antitumor effect. The gene discussed is COL18A1; the disease is lung cancer.