AFP and hepatocellular carcinoma: Owing to the improvement of surgical technique and early diagnostic methods, the resection rate of HCC has increased [1].However, the postoperative relapse and metastatic rate remains high [2].Traditional biomarkers, such as Alpha-fetoprotein (AFP) has limited clinical value in predicting prognosis and metastatic recurrence [3].Thus, it is important to identify new molecular predictive markers.