Whether treating patients suffering from severe sepsis with recombinant CRISPLD2 protein, or other strategies, halts or reverses progression of the disease remains unknown.It would be interesting to monitor CRISPLD2 serum levels in patients with increased risk of developing septic shock while actively inducing a boost in CRISPLD2 concentration once the levels of this protein fall below a critical threshold. This evidence concerns the gene CRISPLD2 and Sepsis.