PML, listed in CancerGenes and cited in the literature as CRC related, was the only TF among the 16 TFs that came exclusively from the IBD sequence; the four TFs CEBPB, E2F5, MYC, and RUVBL1 were common to both the Ade and IBD sequences; the remaining 11 came exclusively from the Ade sequence (Table 4). This evidence concerns the gene E2F5 and colorectal carcinoma.