To our surprise, CSTP1 mRNA was decreased significantly (by 40%∼90%) in 80% (8 of 10) of bladder cancer tissues as compared to paired adjacent non-cancerous tissues, whereas the expression of CSTP1 mRNA in liver, pancreas, stomach, colon and renal cancer tissues did not change significantly (Fig. 1A). This evidence concerns the gene CSTP1 and urinary bladder cancer.