The eyes of aged, targeted-replacement apoE mice expressing human Apo E4, (HuApoE4 KI), when placed on a high fat diet developed changes which mimic AMD pathology with diffuse sub-RPE deposits, Bruch’s membrane thickening, RPE atrophy, both hypopigmentation and hyperpigmentation of the RPE [3]. The gene discussed is APOE; the disease is age-related macular degeneration.