NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic disorder caused by mutations in the NOTCH3 gene, which maps to chromosome 19 and encodes the transmembrane receptor NOTCH3 [1], [2].