In this context, it should be noted that currently there is no evidence for modulation of the Enpp1asj mutation by other genes, such as Abcc6 in PXE mice (Klement et al., 2005) or in some inbred strains of mice (KK/HlJ, DBA/2J and C3H/HeJ) (Berndt et al., 2013) associated with vascular mineralization. Here, ABCC6 is linked to pseudoxanthoma elasticum (inherited or acquired).