RAPGEF3 and melanoma: Similar ambiguity exists for another primary cAMP effector: selective activation of EPAC inhibited the migration of PC-3 prostate carcinoma cells [16], MDCK-GFP-EPAC kidney epithelial cells [28] and H295 adrenocortical carcinoma cells [2], but potentiated migration of SK-Mel-2 melanoma cells [3].