Many pigmentation genes linked to melanoma in recent GWAS such as TPCN2, ASIP, KIT, NCKX5, TYR, IRF 4, OCA2 and TYRP1 have been linked to melanoma and some of them like MC1R have dual roles in pigmentation and immune responses but many other functions of these genes remain to be discovered [30]. This evidence concerns the gene OCA2 and melanoma.