Assessment of response rates (HbA1c reduction ≥ 1% in the add-on studies and ≥ 2% in the initial combination study) in patients stratified by baseline demographic and clinical categorical covariates (sex, age, duration of diabetes, BMI, HbA1c, C-peptide AUC, insulin AUC, glucagon AUC, glucose AUC and insulin secretion) suggested only isolated correlations with response rates. Here, INS is linked to diabetes mellitus.