KDM1A and sickle cell disease: Two independent studies have described that RNAi-mediated or chemical inhibition of Lsd1 enhances γ-globin expression in human erythroid cells and quite modestly in human β-locus transgenic mice (Shi et al., 2013; Xu et al., 2013), which would alleviate symptoms of β-hemoglobinopathies such as sickle cell disease and β-thalassemia.