SCD patients show reduced bioavailability of NO as well as late onset of menarche.9 An earlier study in state of Odisha (India) found late onset of menarche among SCD females (14.9 ± 1.55 years) compared to that of normal females (13.7 ± 1.37 years).10 Moreover, reports are lacking on the role of genetic factors linking menarche and eNOS gene polymorphism with the age of onset of menarche in SCD females. Here, NOS3 is linked to Schnyder corneal dystrophy.