NOS3 and Schnyder corneal dystrophy: Deficient eNOS gene and reduced synthesis of nitric oxide, in mice models and human, have been found to be associated with impaired fetal development, placental abruption, recurrent miscarriages and death of fetus in utero.7,30,31 Thus SCD pubescent girls showing late onset of menarche (because these females are associated with mutant eNOS gene and low level of nitric oxide) may be at risk of acquiring these morbidities during pregnancy in future as compared to early menarche group.