The present findings are contradictory to earlier findings on healthy and normal Caucasian females which showed complete absence of association of menarche with these eNOS polymorphisms.8 Our study reveals that the mean age of menarche of 13.1 years normal/controls was delayed by 4.0 years in SCD females as observed in Jamaican SCD girls9 which indicates that ethnic variation may be associated with menarche. Here, NOS3 is linked to Schnyder corneal dystrophy.