KISS1 and Schnyder corneal dystrophy: A recent study of candidate genes associated with age onset of menarche assigned 42 SNPs of 9 genes (FSHB, LHCGR, POMC, UGT2B4, GHRH, CD40LG, FGFR1, KISS1, NKX2-1) among Caucasian normal females.29 Thus, the present finding of association between eNOS gene and menarche, assign eNOS gene to be an additional genetic modulator of menarche in SCD females.