In MF enrichment patterns, the cancer genes are highly enriched in ‘protein kinase binding’ (–Log P = 20.8), and ‘regulatory region DNA binding’ (–Log P = 18), yet these two terms are not enriched as highly among obesity/metabolic syndrome-associated genes (–Log P = 3.1 and 1.8, respectively). Here, WEE1 is linked to obesity due to melanocortin 4 receptor deficiency.