The soldiers with sufficient follow-up data available have had a symptomatic improvement after 6 months of GH replacement, with adult growth hormone deficiency QoL assessment (AGHDA-QoL) score falling from 19 to 14 (of 25), and Beck Depression Inventory II (BDI-II) score from 36 to 18 (of 63) in 1 subject (M14), and AGHDA-QoL from 14 to 3, and BDI-II falling from 20 to 16 in another (M08) during this period. Here, GH1 is linked to major depressive disorder.