POMC and hypogonadotropic hypogonadism: Opiates can have complex neuroendocrine effects, including induction of hypogonadotrophic hypogonadism, and potentially decreasing ACTH secretion but increasing GH secretion.26 Although there was greater use of opiates in the bTBI as a whole than in the nbTBI group, the individual pituitary dysfunction seen in each soldier within the bTBI group was not explicable by opiate use.