Among those are well-known regulators of aging such as the cell cycle regulators CDKN1A (p21) and OSBP, regulators of muscle cells and energy metabolism like LMOD1 and CHRNA1 or FAT1 and PRODH. These genes with accelerated expression changes in OPMD could contribute to disease progression and muscle weakness. This evidence concerns the gene FAT1 and oculopharyngeal muscular dystrophy.