Among those are well-known regulators of aging such as the cell cycle regulators CDKN1A (p21) and OSBP, regulators of muscle cells and energy metabolism like LMOD1 and CHRNA1 or FAT1 and PRODH. These genes with accelerated expression changes in OPMD could contribute to disease progression and muscle weakness. Here, PRODH is linked to oculopharyngeal muscular dystrophy.