These and other compounds are excellent tools to study BET protein function, but have also shown impressive preclinical promise for the treatment of the NUT midline carcinoma (JQ1, [75]), specific types of leukemia (JQ1 [80], I-BET151 [77]) inflammation (I-BET [76], MS417 [78]), and viral infections, including HIV. This evidence concerns the gene DNER and viral infectious disease.