While their antiangiogenic activity is due to inhibition of the secretion of VEGF, bFGF, Interleukin-8 or TNFα and fibroblast growth factor (FGF) from tumor and tumor stroma cells, their immunomodulatory effect is caused by stimulation of T-cells and natural killer cells as well as the inhibition of T-regulatory cells [59]. The gene discussed is VEGFA; the disease is neoplasm.