PTGS2 and arthritic joint disease: Inhibitors of COX-2, both traditional nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and diclofenac, which inhibit both COX-1 and COX-2, and newer selective COX-2 agents, such as rofecoxib and celecoxib (2), have been widely used for the treatment of arthritis and other inflammatory conditions.