In accordance with the transcription data, we found a decrease in IL12p40 protein secreted from PBMCs from patients with MS as compared to healthy controls after TLR8 stimulation (mean ± SE = 717.7 ± 211.3 versus 2,401 ± 285.4 pg/ ml; P <0.005) but not after PHA stimulation (mean ± SE = 843.5 ± 287.6 versus 709.4 ± 169.8 pg/ ml; P >0.05) (Figure 2) indicating the cells from patients with MS were capable of responding to the same level as cells from healthy donors. This evidence concerns the gene TLR8 and myeloid sarcoma.