This is consistent with mouse studies that revealed that diets containing up to 5% oleate did not rescue the low fat stores in SCD1 mutants (50) and with human studies that showed that diets high in oleic acid, such as a Mediterranean diet, provide a protective role against obesity, whereas diets high in saturated fats and simple carbohydrates, which induce endogenous SCD activity, lead to excess fat stores (51). Here, SCD is linked to obesity disorder.