TGFB1 and neoplasm: The increasing amount of TGFβ1 is correlated with a high incidence of distant metastasis as TGFβ acts on the tumor cells and the surrounding stroma to promote epithelial to mesenchymal transition (EMT), ECM degradation, cell migration, cell invasion, angiogenesis, immunosuppression and modification of the tumor microenvironment [8-11].