Four transcripts [RORB, Indian Hedgehog gene (IHH), DLG7 (DLGAP5), and MELK] whose expression levels were identified as altered by hybridization-based microarray analysis in the discovery set were chosen for validation in an external sample set comprised of 58 endometrial cancer (40 endometrioid and 18 serous) and 25 normal endometrial (7 post-menopausal and 18 pre-menopausal) tissue specimens utilizing by qRT-PCR (Figure 3). Here, MELK is linked to endometrial cancer.