A comparison of the endometrial cancers (serous and endometrioid) versus normal post-menopausal endometrium control gene list using the MetaCore (GeneGo) pathway and ontology mining database revealed enrichment of pathways involved in cell cycle, cytoskeletal remodeling, chemokines in cell adhesion, and several signaling pathways including PTEN, Wnt, Flt, and CREB (Figure 5). This evidence concerns the gene PTEN and endometrial cancer.