VHL and neoplasm: In high grade tumours, pVHL expression was predominantly cytoplasmic (grade 4 vs. grade 2: p=0.0035; grade 4 vs. grade 3: p=0.002; Figure 3B), while in low grade tumours, pVHL was mostly membrane-associated (grade 2 vs. grade 4: p=0.0285; Figure 3C).