Although these experimental findings are unique, they are consistent with reports that fibulin-2 is part of a gene expression signature in primary epithelial tumors that predicts the presence of occult metastasis, and that fibulin-2 may promote the metastatic potential of pancreatic cancer cells through its interactions with MUC4 [10,17]. The gene discussed is MUC4; the disease is familial pancreatic carcinoma.