TNFRSF18 and Miyoshi myopathy: Notably, primary MM cells and MM cell lines presented with a similar methylation pattern: specifically, the hypermethylation was mainly demonstrated within the first 130 base pairs of CpG island located at the promoter region In addition, we found that expression of GITR negatively correlated with the promoter CGI methylation status, indicating that loss of GITR expression correlates with aberrant DNA methylation in MM cells (Figure 1e).