We therefore evaluated the expression of TNFRSFs in primary MM cells by analyzing GEO dataset GSE2658 and found that 7 members of the TNFRSF family includingTNFFSF18 (GITR), TNFRSF11A, TNFRSF9, TNFRSF19, TNFRSF8, TNFRSF21 and TNFRSF11B exhibited lower expression levels in MM cells compared to their normal cellular counterpart (Figure S1a). This evidence concerns the gene TNFRSF21 and Miyoshi myopathy.