Cells (tumor associated macrophages (TAM), myeloid derived suppressor cells (MDSC), tumor associated dendritic cells, mesenchymal stromal cells and tumor cell itself) within TME produce several angiogenic growth factors, like, VEGF, PDGF, TGFβ and HGF that stimulate tumor cell proliferation [5], [6]. Here, TGFB1 is linked to neoplasm.